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Desloratadine
Clinical data
Trade namesClarinex (US), Aerius, Dasselta, Deslordis (EU), others
AHFS/Drugs.comMonograph
MedlinePlusa602002
License dataEU  EMA:  by INN, US   FDA: Desloratadine
Pregnancy categoryAU: B1 US: C (Risk not ruled out)
Routes of administrationOral (tablets, solution)
ATC codeR06AX27 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) CA : OTC UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
BioavailabilityRapidly absorbed
Protein binding83 to 87%
MetabolismUGT2B10, CYP2C8
Metabolites3-Hydroxydesloratadine
Onset of actionwithin 1 hour
Elimination half-life27 hours
Duration of actionup to 24 hours
Excretion40% as conjugated metabolites into urine Similar amount into the feces

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The results of these studies demonstrated the efficacy and safety of Clarinex 5 mg in the treatment of adult and adolescent patients with seasonal allergic rhinitis.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

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