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Doxepin
Clinical data
Trade namesSinequan, Quitaxon, Aponal, others [2]
AHFS/Drugs.comMonograph
MedlinePlusa682390
License dataUS   FDA: Doxepin
Pregnancy categoryAU: C US: B (No risk in non-human studies)
Routes of administrationBy mouth, topical, intravenous, intramuscular injection [1]
Drug classTricyclic antidepressant (TCA)
ATC codeD04AX01 ( WHO ) N06AA12 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability13–45% (mean 29%) [5] [6]
Protein binding76% [7]
MetabolismHepatic (CYP2D6, CYP2C19) [4] [5]
MetabolitesNordoxepin, glucuronide conjugates [4]
Elimination half-lifeDoxepin: 8–24 hours (mean 17 hours) [7] Nordoxepin: 31 hours [7]
ExcretionUrine: ~50% [4] [5] Feces: minor [5]

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