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As of March2018, no guidelines have been published that reflect the results of this trial. Demographics: 68% male, mean age 66 years, admission from medicine ward 81 Infection: community acquired 76% unknown site 3% Lung 58% Abdomen 11% Urinary tract 18% Positive blood culture 37% Gram-positive 70% Gram-negative 42% how to wean off fludrocortisone antimicrobial therapy 96 Hydrocortisone 50mg IV every 6 hours and fludrocortisone 50 mcg NG daily for 7 days without taper Activated protein C 24 mcg/kg/h for 96 h 1 This arm discontinued follow withdrawal of the product from the market Placebo mannitol 133.Before taking fludrocortisone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

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