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En un estudio de toxicidad en animales j venes, forxiga company se administr dapagliflozina directamente a ratas j venes desde el d a 21 despu s del nacimiento hasta el d a 90 despu s del nacimiento, se notificaron dilataciones p lvicas y tubulares forxiga company con todas las dosis; la exposici n de las cr as tratadas con la dosis m s baja fue 15 veces avon a la exposici n observada con la dosis m xima recomendada en humanos.

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Adachi T, Yasuda K, Okamoto Y, Shihara N, Oku A, Ueta K, Kitamura K, Saito A, Iwakura I, Yamada Y, Yano H, Seino Y, Tsuda K. T-1095, a dapagliflozin class Naglucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced dapagliflozin class rats./paragraph paragraph Based on animal data showing adverse renal effects, FARXIGA is not recommended during the second and third trimesters of pregnancy.

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Diabetes Care.001, Tables 5 and 6 These effects were sustained in longer-term studies.

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