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The incidence of levodopa-induced nausea and vomiting is less with the combination product than with levodopa.When a greater proportion of carbidopa is required, one tablet of Levodopa 25mg 25-100 may be substituted for each tablet of SINEMET 10-100. When more levodopa is required, SINEMET 25-250 levodopa 25mg be substituted for SINEMET 25-100 or SINEMET 10-100.

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