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|Trade names||Cilest, Ortho-Cyclen, Ortho Tri-Cyclen, Prefest, Previfem, Sprintec, TriNessa, Tri-Cyclen, Tri-Sprintec, others|
|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
|Routes of administration||By mouth|
|Drug class||Progestin; Progestogen; Progestogen ester |
|ATC code||G03AA11 ( WHO ) G03FA13 ( WHO ) (only combinations with estrogens)|
|Legal status||US: ℞-only|
|Protein binding||• Norelgestromin: 99% (to albumin)  • Levonorgestrel: 98% (to albumin and SHBG)  • Levonorgestrel acetate: ? (to albumin) |
|Metabolism||Liver, intestines (deacetylation, reduction, hydroxylation, conjugation)   |
|Metabolites||• Norelgestromin  • Levonorgestrel  • Levonorgestrel acetate |
|Elimination half-life||• Norgestimate: very short  • Norelgestromin: 17–37 hours   • Levonorgestrel: 24–32 hours |
|Excretion||Urine: 47%  Feces: 37% |
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Adverse effects associated with Tri-Lo-Sprintec include headache, nausea, breast issues, abdominal pain, mood disorders, acne, and fatigue. In a clinical trial observing 1673 subjects during 11, 03 cycles of Tri-Lo-Sprintec, researchers recorded 20 pregnancies.rig1s034ltr.
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