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Clinical data
Trade namesCilest, Ortho-Cyclen, Ortho Tri-Cyclen, Prefest, Previfem, Sprintec, TriNessa, Tri-Cyclen, Tri-Sprintec, others
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of administrationBy mouth
Drug classProgestin; Progestogen; Progestogen ester [1]
ATC codeG03AA11 ( WHO ) G03FA13 ( WHO ) (only combinations with estrogens)
Legal status
Legal statusUS: ℞-only
Pharmacokinetic data
BioavailabilityUnknown [4]
Protein binding• Norelgestromin: 99% (to albumin) [1] • Levonorgestrel: 98% (to albumin and SHBG) [1] • Levonorgestrel acetate: ? (to albumin) [1]
MetabolismLiver, intestines (deacetylation, reduction, hydroxylation, conjugation) [1] [2] [3]
Metabolites• Norelgestromin [1] • Levonorgestrel [1] • Levonorgestrel acetate [1]
Elimination half-life• Norgestimate: very short [1] • Norelgestromin: 17–37 hours [2] [1] • Levonorgestrel: 24–32 hours [1]
ExcretionUrine: 47% [3] Feces: 37% [3]

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Synonym: ORTHO TRI-CYCLEN , TRINESSA, TRIVORA. AHFS Type: CONTRACEPTIVES (68.12.00). 1) Triphasic contraceptive containing:

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Adverse effects associated with Tri-Lo-Sprintec include headache, nausea, breast issues, abdominal pain, mood disorders, acne, and fatigue. In a clinical trial observing 1673 subjects during 11, 03 cycles of Tri-Lo-Sprintec, researchers recorded 20 pregnancies.rig1s034ltr.

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